Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

By D. Dinulescu, T. Ince, B. Quade, Sarah A Shafer, D. Crowley, T. Jacks. Nature Medicine, 2005

608 citations recorded by the source corpus.

Subfields: Obstetrics and Gynecology, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/562072ff4f7128ba26b3f58cbf46c352b9f13850

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Obstetrics and Gynecology

1. J. Prat
2. E. Lengyel

In Reproductive Medicine

1. J. Prat
2. E. Lengyel
3. Ankur K. Nagaraja
4. M. Matzuk
5. M. Edson

Citations in the corpus

• Pathogenesis and Pathophysiology of Endometriosis (2012, unknown): “…Aromatase enzyme Noble et al 1996 (101) HOXA10 Transcription factor Taylor et al 1999 (102) IL-6 Cytokine Harada et al 1997 (81) KRAS Oncogene Dinulescu et al 2005 (30) MMP 3,7 Matrix metalloproteinases Bruner-Tran et al 2002 (65) NF-KB Transcription factor Gonzalez-Ramos et al 2010…”
• Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features (2012, background): “In mice harboring KRAS mutations that result in the development of benign lesions reminiscent of endometriosis, deletion of PTEN leads to the induction of invasive endometrioid carcinoma [65].”
• Ovarian cancer development and metastasis. (2010, background): “When the two mutations were combined, the mice developed metastatic ovarian carcinoma, which often appeared endometrioid.(27,28) The sequence of genetic events in high-grade serouspapillary carcinomas is not as well understood.”
• The mammalian ovary from genesis to revelation. (2009, methodology): “(511, 512) used the intrabursal AdCre-loxP system to simultaneously activate an oncogenic Kras allele and delete the Pten tumor suppressor in murine OSE.”
• Discovery of multi-dimensional modules by integrative analysis of cancer genomic data (2012, background): “These pathways include TGF-β signaling, Hedgehog signaling, bladder cancer, and cytokine-cytokine receptor interaction pathways, all of w hich have been confirmed to be closely associated with ovarian cancer (27, 28, 29, 30, 31, 32).”