Control of Local Protein Synthesis and Initial Events in Myelination by Action Potentials

By H. Wake, Philip R. Lee, R. Fields. Science, 2011

627 citations recorded by the source corpus.

Axons signal through both glutamate and adenosine triphosphate release to regulate their insulating wraps. Formation of myelin, the electrical insulation on axons produced by oligodendrocytes, is controlled by complex cell-cell signaling that regulates oligodendrocyte development and myelin formation on appropriate axons. If electrical activity could stimulate myelin induction, then neurodevelopment and the speed of information transmission through circuits could be modified by neural activity. We find that release of glutamate from synaptic vesicles along axons of mouse dorsal root ganglion neurons in culture promotes myelin induction by stimulating formation of cholesterol-rich signaling domains between oligodendrocytes and axons, and increasing local synthesis of the major protein in the myelin sheath, myelin basic protein, through Fyn kinase-dependent signaling. This axon-oligodendrocyte signaling would promote myelination of electrically active axons to regulate neural development and function according to environmental experience.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/2e2eccba53702409c4fd40689fa0a7a18968fca6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013, background): “Ultimately, the biochemical pathways that control OL maturation, myelination, and morphology might be stimulated by electrical activity in axons (Wake et al., 2011).”
Prolonged myelination in human neocortical evolution (2012, background): “Myelination is ubiquitous throughout the nervous system of vertebrates and plays a dynamic role in regulating the functional activity of axons (10, 11).”
Oligodendrocytes: Myelination and Axonal Support. (2015, background): “Subsequently,thelocaltrans-lation of MBP is initiated at the tip of the glial process, whichis in contact with the axon invivo (or in the outermost edge of the oligodendrocyte in vitro) (White et al. 2008; Laursen et al. 2011; Wake et al. 2011).”
Differences in White Matter Fiber Tract Development Present from 6 to 24 Months in Infants with Autism (2012, background): “In typical development, the selective refinement of neural connections via axonal pruning (54), along with constructive processes such as myelination (55), combine to yield efficient signal transmission among brain regions.”
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain (2017, positive): “Recent studies propose that AMPA and kainate receptors mediate an initial axon-OPC synaptic response to glutamate that directs OPCs to exposed axonal sites where NMDA receptor activation directs remyelination 40–44 .”
Neuronal activity-dependent control of postnatal neurogenesis and gliogenesis (2018, neutral): “1989, Kirchhoff & Kettenmann 1992, H. Wang et al. 2003).”
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication (2013, background): “translation of the major myelin protein MBP, thus promoting myelination [5].”