Titanium Surface Characteristics, Including Topography and Wettability, Alter Macrophage Activation

By Kelly M Hotchkiss, Gireesh B. Reddy, S. Hyzy, Z. Schwartz, B. Boyan, R. Olivares-Navarrete. Acta Biomaterialia, 2015

617 citations recorded by the source corpus.

Biomaterial surface properties including chemistry, topography, and wettability regulate cell response. Previous studies have shown that increasing surface roughness of metallic orthopaedic and dental implants improved bone formation around the implant. Little is known about how implant surface properties can affect immune cells that generate a wound healing microenvironment. The aim of our study was to examine the effect of surface modifications on macrophage activation and cytokine production. Macrophages were cultured on seven surfaces: tissue culture polystyrene (TCPS) control; hydrophobic and hydrophilic smooth Ti (PT and oxygen-plasma-treated (plasma) PT); hydrophobic and hydrophilic microrough Ti (SLA and plasma SLA), and hydrophobic and hydrophilic nano-and micro-rough Ti (aged modSLA and modSLA). Smooth Ti induced inflammatory macrophage (M1-like) activation, as indicated by increased levels of interleukins IL-1β, IL-6, and TNFα. In contrast, hydrophilic rough titanium induced macrophage activation similar to the anti-inflammatory M2-like state, increasing levels of interleukins IL-4 and IL-10. These results demonstrate that macrophages cultured on high surface wettability materials produce an anti-inflammatory microenvironment, and this property may be used to improve the healing response to biomaterials.

Subfields: Biomedical Engineering, Surfaces, Coatings and Films, Surgery

View Paper: https://www.semanticscholar.org/paper/525dab37493bd886d1439f51d667496e5fa7985f

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Citations in the corpus

Macrophages in immunoregulation and therapeutics (2023, methodology): “Hotchkiss and coworkers witnessed that sleek titanium prompted an added inflammatory M1-like phenotype in macrophages; however, coarse titanium elicited an immunoregulatory M2 phenotype.(150) In addition to the titanium, several constituents with unique topographies were utilized to investigate macr”