Drug metabolism and variability among patients in drug response.

By G. Wilkinson. New England Journal of Medicine, 2005

1,226 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2e0b705298aa45583a2cd0bc5aee3678cc6d6342

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In Molecular Biology

Citations in the corpus

THE HUMAN INTESTINAL CYTOCHROME P450 “PIE” (2006, background): “In humans, approximately 80% of oxidative metabolism and almost 50% of the overall elimination of commonly used drugs can be attributed to one or more of the various P450 enzymes that are classified into three families (CYP1, -2, and -3) (Wilkinson, 2005).”
Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. (2007, background): “Polymorphisms in the CYP2C19 gene are shown to affect the metabolism of several classes of drugs, including antidepressants and proton pump inhibitors (PPI; for some recent reviews in this topic, see Ingelman-Sundberg, 2004; Wilkinson, 2005; Klotz, 2006).”
Polymorphism of human cytochrome P450 enzymes and its clinical impact (2009, background): “In humans, almost 50% of the overall elimination of commonly used drugs can be attributed to one or more of the various CYP enzymes (Wilkinson, 2005).”
Pharmacogenomics of Drug Metabolizing Enzymes and Transporters: Relevance to Precision Medicine (2016, background): “Such interindividual variation is often a challenge to optimizing a dosage regimen because most drugs are effective in only 25%–60% of patients [10].”
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, neutral): “Despite the observation that CYP3A4 is rarely polymorphically expressed, the enzyme has been repeatedly demonstrated to show a high inter-individual difference in gene expression (Westlind-Johnsson et al. 2003; Wilkinson 2005).”