THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”

By M. Paine, H. L. Hart, S. S. Ludington, R. Haining, A. Rettie, D. Zeldin. Drug Metabolism And Disposition, 2006

883 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

PBPK models for the prediction of in vivo performance of oral dosage forms. (2014, background): “Enterocytes contain a range of CYP (de Waziers et al., 1990; Paine et al., 2006), and conjugation enzymes (e.g., UGTs, sulfotransferases) (Riches et al., 2009; Strassburg et al., 2000).”
Polymorphism of human cytochrome P450 enzymes and its clinical impact (2009, background): “…the CYPs are expressed appreciably in extrahepatic tissues, including small intestinal mucosa, lung, kidney, brain, placenta, olfactory mucosa, and skin, with the intestinal mucosa probably being the most important extrahepatic site of drug biotransformation (Lin and Lu, 2001; Paine et al., 2006).”
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. (2013, background): “, 2006) and intestine (Paine et al., 2006) appears to be low or absent (Table 2).”