Avian flu: Influenza virus receptors in the human airway

By K. Shinya, M. Ebina, Shinya Yamada, M. Ono, N. Kasai, Yoshihiro Kawaoka. Nature, 2006

1,418 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2defddd66f575b86d6cdddf06648e4e52c13e14e

How researchers see this paper

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In Epidemiology

1. J. Peiris
2. M. D. de Jong
3. Yi Guan
4. M. A. Tortorici
5. Raymond Tellier
6. A. Varki
7. E. De Clercq

In Molecular Biology

1. Yi Guan
2. M. A. Tortorici
3. Wentao Li
4. A. Varki
5. Guangchuang Yu
6. R. Schauer

Citations in the corpus

• Antiviral agents active against influenza A viruses (2006, background): “Avian (H5N1) influenza viruses and human (H3N2, H1N1) influenza viruses seem to target different receptors of the human respiratory tract: whereas humanderived viruses preferentially recognize SAα2,6Gal located on epithelial cells of the nasal mucosa, paranasal sinuses, pharynx, trachea and bronchi,”
• Avian Influenza Virus (H5N1): a Threat to Human Health (2007, background): “The propensity of current H5N1 viruses to cause lower respiratory tract infections is in accord with the presence of avian-type SA -2,3 Gal receptors to which avian viruses can bind in human bronchiolar and alveolar cells (192, 243).”
• Review of Aerosol Transmission of Influenza A Virus (2006, background): “Recent studies have shown that whereas epithelial cells in the human respiratory tract express predominantly the α-2,6 sialic acid receptor, cells expressing the α-2,3 receptor were detected only occasionally in the upper respiratory tract; however, measurable expression of α-2,3–linked sialic acid ”
• Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein (2017, positive): “For influenza viruses, it has been well established that Sia-binding preference and distribution of Sia species in animals and humans are critical determinants for host and tissue tropism (65, 66, 71, 72).”
• Sialic acids in human health and disease (2008, positive): “Recent examples of severe and even lethal human infections with avian flu might be explained by the fact that these individuals inhaled a very large dose of virus, which reached the lower airways, where α2-3-linked sialic acids are present in humans [80].”