A tiling resolution DNA microarray with complete coverage of the human genome

By A. Ishkanian, C. Malloff, S. Watson, R. deLeeuw, Bryan Chi, Bradley P. Coe, Antoine Snijders, Donna Albertson, Dan Pinkel, Marco A. Marra and 3 more. Nature Genetics, 2004

672 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/2dda4a3a0428b8d0a1d3d9b1265fcdcb2858799f

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Citations in the corpus

Copy number variation: new insights in genome diversity. (2006, background): “However, higher resolution arrays are now being assembled that could be used in such CNV discovery studies, including tiling arrays and higher density oligonucleotide arrays (Ishkanian et al. 2004; Dhami et al. 2005; Selzer et al. 2005; Urban et al. 2006).”
Segmental duplications and copy-number variation in the human genome. (2005, background): “…either limited genomic coverage or limited resolution with respect to regions of segmental duplication, and even current tiling-path arrays with 130,000 BAC clones (Ishkanian et al. 2004) do not achieve complete coverage of regions rich in segmental duplications (Z.C. and E.E.E., unpublished data).”
Chromosome 21 and Down syndrome: from genomics to pathophysiology (2004, methodology): “Finally, comparative genomic hybridization (CGH) on BAC chips can be used for the diagnosis of full trisomy or monosomy, and for partial (segmental) aneuploidie”
X-linked mental retardation (2005, background): “Recently, genome-wide screening for submicroscopic deletions and duplications has become possible owing to the introduction of high-resolution array CGH (comparative genomic hydridization”
PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. (2007, background): “…Comparative Genomic Hybridization (array-CGH) techniques, are limited to detection of CNVs of tens or hundreds of kilobases (Iafrate et al. 2004; Ishkanian et al. 2004; Sebat et al. 2004; Fiegler et al. 2006; Mills et al. 2006; Redon et al. 2006; Carter 2007; Scherer et al. 2007; Wong et al.…”
A statistical approach for array CGH data analysis (2005, background): “Nevertheless, a new generation of arrays now provides a tiling resolution of the genome [15].”
Diagnostic genome profiling in mental retardation. (2005, methodology): “We prepared a tiling-resolution microarray consisting of 32,447 overlapping BAC clones, which were selected to cover the entire human genome (Ishkanian et al. 2004; Krzywinski et al. 2004) and are available at the BACPAC Resources Center Web site, using methodology essentially as described elsewhere”
Duplication and divergence: the evolution of new genes and old ideas. (2004, background): “So far, this high-resolution or “submegabase resolution tiling” array CGH has been used with success to look for variation in gene content only between normal and cancerous cell lines, but comparisons between normal cells/individuals or between different species will, no doubt, soon be reported.”
Array comparative genomic hybridization and its applications in cancer (2005, background): “BAC arrays providing complete genome-tiling paths of mammalian genomes are now being produce”
Fish Gonadogenesis. Part II: Molecular Biology and Genomics of Sex Differentiation (2008, background): “These limitations may, however, be overcome in the future with the development of high-density whole-genome oligonucleotide-based arrays (Ishkanian et al., 2004; Mockler and Ecker, 2005), which have been shown to be more efficient for high-resolution analysis of DNA copy number (Wicker et al.”
Analysis of array CGH data: from signal ratio to gain and loss of DNA regions (2004, positive): “Array Comparative Genome Hybridization (array CGH) is a recently developed technology based on DNA microarrays (Pinkel et al., 1998; Snijders et al., 2001; Solinas-Toldo et al., 1997; Ishkanian et al., 2004) and dedicated to the investigation and mapping of changes in DNA copy number.”
Comparative analysis of algorithms for identifying amplifications and deletions in array CGH data (2005, background): “Tiling or custom arrays are also available now for even finer resolution of specific regions and allow the detection of micro-amplifications and deletions (Lucito et al., 2003; Ishkanian et al., 2004).”
Development of query strategies to identify a histologic lymphoma subtype in a large linked database system. (2006, positive): “By referring the segment to its corresponding position on the human genome map, the genes affected by copy number alteration can be identifi ed (Fiegler et al. 2003; Ishkanian et al. 2004; Snijders et al. 2001).”
A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. (2005, background): “Further increase in resolution was obtained by arrays consisting of 32,433 BAC clones spanning the entire human genome, resulting in comprehensive analyses of cancer genomes at less than 100 kb resolution (7).”