The problem of synergism and antagonism of combined drugs.

By S. Loewe. 1953

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Citations in the corpus

SynergyFinder Plus: Toward Better Interpretation and Annotation of Drug Combination Screening Datasets (2022, background): “As the SynergyFinder R package provides four synergy models ( i.e. , HSA, BLISS, LOEWE, and ZIP) that differ in their null hypotheses of non-interaction, the synergy scores do not necessarily coincide with each other for a given dataset.”
Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities (2018, background): “Drug-drug interactions are defined through the concepts of synergy and antagonism [283, 284] and are quantified biologically by measuring the dose-effect curves [285, 286] or cell viability [287, 288, 289, 290, 280, 291, 292].”
Combenefit: an interactive platform for the analysis and visualization of drug combinations (2016, background): “The three classical models, namely the Loewe (Loewe and Muchnick, 1926; Loewe, 1953), the Bliss (Bliss, 1939; Webb, 1963) and the Highest Single Agent (HSA; Mathews Griner et al. , 2014; Tan et al. , 2012) models have been incorporated.”
Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells (2020, methodology): “…data across a diverse cell line panel were obtained from DeepSynergy (http://www.bioinf.jku.at/software/ DeepSynergy/) (Preuer et al., 2018), which used the Loewe model of additivity (Loewe, 1953) to evaluate the interaction of 583 different drug combinations across 39 human cancer cell lines.”
Searching for Drug Synergy in Complex Dose–Response Landscapes Using an Interaction Potency Model (2015, background): “The Loewe additivity model states that the expected effect y LOEWE must satisfy where X 1LOEWE and X 2LOEWE are thedosesof drug 1 and 2 alonethat produce y LOEWE [6].”
Multicomponent therapeutics for networked systems (2005, background): “, and, in 1928, Loewe and others studied the interaction between other defined drug combination”
Analysis of drug combinations: current methodological landscape (2015, methodology): “In particular dose–effect-based approaches rely on the mathematical framework known as Loewe Additivity, since it was first mentioned by Frei (1913) (Frei 1913) but first defined formally by Loewe (1926) (Loewe 1926, 1927, 1953, 1959).”
Drug synergism: its detection and applications. (2001, unknown): “The isobologram was introduced by Loewe (1953, 1957) but seems to have attracted little attention until it was used in a study of the combination of ethyl alcohol and chloral hydrate (Gessner and Cabana, 1970).”
DeepSynergy: predicting anti-cancer drug synergy with Deep Learning (2017, methodology): “Therefore, we calculated Loewe Additivity values using the batch processing mode of Combenefit (Di Veroli et al. , 2016).”
SynergyFinder: a web application for analyzing drug combination dose–response matrix data (2017, methodology): “Commonly-utilized reference models include the Highest single agent (HSA) model (Berenbaum, 1989), the Loewe additivity model (Loewe, 1953), the Bliss independence model (Bliss, 1939), and more recently, the Zero interaction potency (ZIP) model (Yadav et al.”
Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies (2006, background): “This concept has more than a century of history and has been subjected to decades-long intensive studies by Loewe (1928, 1953, 1957) and Berenbaum (1977, 1981, 1989).”
Network target for screening synergistic drug combinations with application to traditional Chinese medicine (2011, methodology): “Evaluation of multicomponent synergy is usually implemented experimentally in a case-by-case approach [4] and evaluated using the reference models of additivism to recognize synergy such as the Bliss independence model [5], the Loewe additivism model [6] and the Combination Index theorem [7].”