Combenefit: an interactive platform for the analysis and visualization of drug combinations
By G. Y. Veroli, Chiara Fornari, Dennis Wang, S. Mollard, J. L. Bramhall, F. Richards, D. Jodrell. Bioinform., 2016
627 citations recorded by the source corpus.
Motivation: Many drug combinations are routinely assessed to identify synergistic interactions in the attempt to develop novel treatment strategies. Appropriate software is required to analyze the results of these studies. Results: We present Combenefit, new free software tool that enables the visualization, analysis and quantification of drug combination effects in terms of synergy and/or antagonism. Data from combinations assays can be processed using classical Synergy models (Loewe, Bliss, HSA), as single experiments or in batch for High Throughput Screens. This user-friendly tool provides laboratory scientists with an easy and systematic way to analyze their data. The companion package provides bioinformaticians with critical implementations of routines enabling the processing of combination data. Availability and Implementation: Combenefit is provided as a Matlab package but also as standalone software for Windows (http://sourceforge.net/projects/combenefit/). Contact: Giovanni.DiVeroli@cruk.cam.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.
Subfields: Computational Theory and Mathematics, Experimental and Cognitive Psychology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/16ab04e02d469ca9b3e9357923d2712fbe6d45ac
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In Computational Theory and Mathematics
- Sepp Hochreiter
- Günter Klambauer
- Andreas Bender
- Kristina Preuer
- Tolou Shadbahr
- Alberto Pessia
- Wenyu Wang
- Richard P. I. Lewis
In Pharmacology
Citations in the corpus
- DeepSynergy: predicting anti-cancer drug synergy with Deep Learning (2017, methodology): “Therefore, we calculated Loewe Additivity values using the batch processing mode of Combenefit (Di Veroli et al. , 2016).”
- SynergyFinder Plus: Toward Better Interpretation and Annotation of Drug Combination Screening Datasets (2022, methodology): “Previously developed tools that can analyze drug combination synergy include COMPUSYSN [9], BRAID [10], Combenfit [11], SynergyFinder [12], and Synergy [13].”