Multicomponent therapeutics for networked systems
By Curtis T. Keith, A. Borisy, Brent R. Stockwell. Nature reviews. Drug discovery, 2005
758 citations recorded by the source corpus.
Subfields: Computational Theory and Mathematics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/480f3e328faa329c5aa2e552d2d95c5ac08bf3be
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In Computational Theory and Mathematics
In Molecular Biology
Citations in the corpus
- Systems biology approaches for advancing the discovery of effective drug combinations (2015, background): “Table 1 Resources for systems analysis of drug combinations results, making it easier to compute [19].”
- Network Pharmacology: A New Approach for Chinese Herbal Medicine Research (2013, background): “The increased understanding of the role of network biology systems challenges the dominant assumption of single-target drug discovery [11, 12].”
- Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery (2011, background): “Multi-target agents directed at selected multiple targets have been increasingly explored for enhanced therapeutic efficacies, improved safety profiles and reduced resistance activities by simultaneously modulating the activity of a primary target and the counteractive elements (3,37,38).”
- Systems biology and combination therapy in the quest for clinical efficacy (2006, background): “The combined effect of the rocks and nails can then be found by correctly combining the individual probabilities that an egg will be hit as the union of independent rock and nail events, which after rearrangement results in equation (5).”
- Network target for screening synergistic drug combinations with application to traditional Chinese medicine (2011, background): “Multicomponent therapeutics, in which two or more agents interact with multiple targets simultaneously, is considered as a rational and efficient form of therapy designed to control complex diseases [1,2].”
- Natural products and drug discovery (2009, background): “Their complex evolutionary histories mean that the structures of natural compounds are highly likely to generate secondary effects and their efficacy often depends on synergistic interactions with other components (Keith et al, 2005).”
- Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review (2012, background): “• Experimental testing of drug combinations may uncover unexpected effects in drug–drug interactions, which may be used for selection of multi-target sets (Borisy et al., 2003; Keith et al., 2005; Dancey & Chen, 2006; Yeh et al., 2006; Lehár et al., 2007; Jia et al., 2009; Liu et al., 2010b).”
- Curcumin as "Curecumin": from kitchen to clinic. (2008, neutral): “[204] Keith CT, Borisy AA, Stockwell BR.”