The dynamic genome of Hydra

By Jarrod Chapman, E. Kirkness, O. Simakov, S. Hampson, T. Mitros, Therese Weinmaier, Thomas Rattei, Prakash G. Balasubramanian, Jon Borman, D. Busam and 64 more. Nature, 2010

805 citations recorded by the source corpus.

The freshwater cnidarian Hydra was first described in 1702 and has been the object of study for 300 years. Experimental studies of Hydra between 1736 and 1744 culminated in the discovery of asexual reproduction of an animal by budding, the first description of regeneration in an animal, and successful transplantation of tissue between animals. Today, Hydra is an important model for studies of axial patterning, stem cell biology and regeneration. Here we report the genome of Hydra magnipapillata and compare it to the genomes of the anthozoan Nematostella vectensis and other animals. The Hydra genome has been shaped by bursts of transposable element expansion, horizontal gene transfer, trans-splicing, and simplification of gene structure and gene content that parallel simplification of the Hydra life cycle. We also report the sequence of the genome of a novel bacterium stably associated with H. magnipapillata. Comparisons of the Hydra genome to the genomes of other animals shed light on the evolution of epithelia, contractile tissues, developmentally regulated transcription factors, the Spemann–Mangold organizer, pluripotency genes and the neuromuscular junction.

Subfields: Cell Biology, Global and Planetary Change, Paleontology

View Paper: https://www.semanticscholar.org/paper/2cdbc13fd7182bf95f0a3b5301f519d756b7d19f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Alexandra Naba
2. M. Takeichi
3. T. Harris
4. R. Hynes
5. V. Weis
6. U. Tepass
7. Peter Friedl
8. Stephanie Alexander

In Global and Planetary Change

1. G. Edgecombe
2. Gonzalo Giribet
3. Casey W. Dunn
4. V. Weis
5. Denis Allemand
6. Zhi-qiang Zhang
7. A. Turner
8. M. Norell

In Paleontology

1. Gonzalo Giribet
2. G. Edgecombe
3. Casey W. Dunn
4. A. Hejnol
5. Sarah L. Boyer
6. Zhi-qiang Zhang
7. Prashant P. Sharma
8. A. Kury

Citations in the corpus

• Overview of the matrisome--an inventory of extracellular matrix constituents and functions. (2012, background): “Many, but not all, of these genes are also found in more primitive metazoan organisms such as cnidaria and sponges (Putnam et al. 2007; Chapman et al. 2010; Srivasatava et al. 2010).”
• Animal Phylogeny and Its Evolutionary Implications (2014, background): “The sampling of cnidarian genomes is only slightly better (Chapman et al. 2010, Putnam et al. 2007, Shinzato et al. 2011).”
• Structural and functional diversity of cadherin at the adherens junction (2011, background): “The recently available ge­ nomes of two cnidarian species, Nematostella vectensis and Hydra magnipapillata, and a placozoan species, Trichoplax adhaerens, revealed that they have conserved classical cadherin cytoplasmic domains (Abedin and King, 2008; Chapman et al., 2010; Hulpiau and van Roy, 2011)”
• Adherens junctions: from molecules to morphogenesis (2010, background): “Genomic sequencing has now revealed classic cadherins in the cnidarians Nematostella vectensis and Hydra magnipapillata , and possibly in sponge”
• Cell Biology of Cnidarian-Dinoflagellate Symbiosis (2012, background): “The publishing of the nonsymbiotic cnidarian genome sequences for the anemone Nematostella vectensis (292) and the hydroid Hydra magnipapillata (46) and of the symbiotic cnidarian genome sequence for the scleractinian coral Acropora digitifera (328), along with numerous other genomic and transcripto”