APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

By X. Mao, Chintan K. Kikani, Ramon A. Riojas, P. Langlais, Lixin Wang, Fresnida J. Ramos, Q. Fang, C. Christ-Roberts, Jenny Y. Hong, R. Kim and 2 more. Nature Cell Biology, 2006

676 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/63f533d5334c057dbab1c295c91997046bd6b800

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. P. Scherer
2. Sushil Kumar Jain
3. A. Achari
4. Haiming Cao
5. M. Blüher

In Molecular Biology

1. P. Scherer
2. Sushil Kumar Jain
3. A. Achari

In Physiology

1. Sushil Kumar Jain
2. A. Achari
3. P. Scherer
4. Haiming Cao
5. M. Blüher

Citations in the corpus

• Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction (2017, background): “APPL2 is an isoform of APPL1, and these two proteins display 54% identity in protein sequences [43].”
• Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, neutral): “Adiponectin binds and stimulates interaction of the N-terminal cytoplasmic domain of its receptor with and intracellular adaptor protein to activate intracellular pathways (418) including p38 MAPK, AMPK, and PPARα.”
• Adiponectin Regulation and Function (2018, neutral): “In 2006, an adaptor protein containing a pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1), was identified for adiponectin (197).”
• Adiponectin: mechanistic insights and clinical implications (2012, background): “Also, in some cell types, the adaptor protein APPL1 has been implicated as a downstream mediator of adiponectin signalling through its interaction with the adiponectin receptors [15].”