LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity.

By Y. Mizutani, A. Kihara, Y. Igarashi. 2006

182 citations recorded by the source corpus.

Subfields: Biochemistry, Cell Biology, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Michal Levy
2. Yusuf A. Hannun
3. S. Alexander
4. Hannah Alexander
5. A. Mesika
6. J. Min
7. M. Sivaguru
8. P. V. Van Veldhoven

In Cell Biology

1. A. Futerman
2. J. Bielawski
3. S. Alexander
4. Hannah Alexander
5. A. Mesika
6. J. Min
7. Yusuf A. Hannun
8. Michal Levy

In Molecular Biology

1. A. Futerman
2. Michal Levy
3. S. Alexander
4. Hannah Alexander
5. Yusuf A. Hannun
6. A. Mesika
7. J. Bielawski
8. J. Min

Citations in the corpus

• Mammalian Ceramide Synthases (2010, background): “Interestingly, when human CerS5 was expressed in a yeast Dlag1Dlac1DLip1 mutant (71), it was able to synthesize C16-ceramides and the mutant survived in the absence of the C26-ceramides that are normally found in yeast.”
• An overview of sphingolipid metabolism: from synthesis to breakdown (2010, unknown): “water barrier in the epidermis [24], [25].”
• (Dihydro)ceramide Synthase 1–Regulated Sensitivity to Cisplatin Is Associated with the Activation of p38 Mitogen-Activated Protein Kinase and Is Abrogated by Sphingosine Kinase 1 (2007, background): “The mammalian enzymes have unique but greatly overlapping tissue distributions (21, 22, 28), but the precise roles of these enzymes and their unique products are not known.”
• Potentiation of cannabinoid-induced cytotoxicity in Mantle Cell Lymphoma through modulation of ceramide metabolism (2009, background): “CerS3 is regarded as a minor CerS that has mainly been described in skin and testis (10, 39) and has been shown to synthesize the longer ceramide”
• Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2 (2008, unknown): “Two other CerS, namely CerS3 and CerS4, have been reported to accept VLCFA-CoAs (>C18) as substrates (Riebeling et al. 2003; Mizutani et al. 2005, 2006).”
• Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing (2009, unknown): “The different CerS enzymes have unique patterns of tissue expression, implying transcriptional regulation in different tissues [9,13,14].”