Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population

By M. Vignuzzi, J. Stone, Jamie J. Arnold, C. Cameron, Raul Andino. Nature, 2006

1,110 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/2c2fb431cd9db3d4a7a0e933f32f3a6da8ba4f03

How researchers see this paper

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In Genetics

1. Jeff Clune
2. Edward C. Holmes
3. Dusan Misevic
4. Richard E. Lenski
5. Siobain Duffy
6. Yong‐Zhen Zhang
7. Santiago F. Elena
8. Rafael Sanjuán

In Molecular Biology

1. Siobain Duffy
2. Joshua Quick
3. Edward C. Holmes
4. Rafael Sanjuán
5. Charles Ofria
6. Yong‐Zhen Zhang
7. Nicola Chirico
8. Richard E. Lenski

In Plant Science

1. Edward C. Holmes
2. Siobain Duffy
3. Yong‐Zhen Zhang
4. A. Imdorf
5. Raul Andino
6. P. Neumann

Citations in the corpus

• Quasispecies Theory and the Behavior of RNA Viruses (2010, background): “These results suggest that quasispecies diversity, rather than the selection of individual variants, correlates with enhanced virulence [76].”
• The Evolution and Emergence of RNA Viruses (2009, background): “While this is clear from the initial estimates of mutation rate made by Jan Drake and colleagues, and there is good evidence that the fi delity of RNA polymerase can be manipulated experimentally (Vignuzzi et al. 2005), and that it may vary according to the host species infected (Pita et al.”
• Viral Mutation Rates (2010, background): “0), and individual plaques were isolated (90).”
• Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak (2006, background): “S 5-Mar-06 Classical n.i. Vf aThis patient travelled back from Comoros and is believed to have been infected there. bS, serum; P, plasma; CSF, cerebrospinal fluid; AF, amniotic fluid. cIsolates labelled with (G) correspond to those for which the nearly complete genome sequence was established. dA, a”
• An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar (2018, background): “Generation of intrahost genetic diversity allows virus populations to evade host immune responses [2–4], alter the severity of disease [5], and adapt to changing environments [6, 7].”
• Natural Selection Fails to Optimize Mutation Rates for Long-Term Adaptation on Rugged Fitness Landscapes (2008, methodology): “Also, given the difficulty of optimizing mutation rates that we have shown, it seems unlikely that stably high mutation rates, such as those for RNA viruses, are maintained primarily because of the rapid adaptive capacity they bestow, as has sometimes been argued [23,41].”
• Virus infections and winter losses of honey bee colonies (Apis mellifera) (2010, background): “Suitable mutations or recombination facilitating transmission of the mutant quasi species (Vignuzzi et al., 2006) in both bees and mites may not occur in all years to the same extent, thereby having a significant impact on the observed viral loads of colonies.”
• Why are RNA virus mutation rates so damn high? (2018, background): “On the other hand, their mutation rates are an exploitable Achilles' heel: researchers and clinicians can increase RNA virus mutation rates using nucleoside analogues, and a 3-5-fold increase in mutation rate causes lethal mutagenesis in human-infecting viruses like poliovirus and influenza [12, 13]”