Pathogenesis of group A streptococcal infections.

By M. Cunningham. Clinical Microbiology Reviews, 2000

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The immunology of sepsis (2008, background): “Non-opsonizing antibodies against cross-reactive epitopes may nevertheless be important in protective mucosal immunity [99].”
Molecular Mimicry, Bystander Activation, or Viral Persistence: Infections and Autoimmune Disease (2006, background): “This is one of the best examples of molecular mimicry in autoimmune disease (21).”
Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements (2005, background): “Analysis of Streptococcus pyogenes CRISPR Spacers Streptococcus pyogenes is a strict human pathogen (Cunningham 2000) member of the low-G+C group of Gram-positive bacteria.”
Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus (2014, background): “This disease burden includes over 2.4 million cases in patients aged 5 to 14 years, making RHD the most common cause of pediatric heart disease worldwide (73).”
Sortases and the Art of Anchoring Proteins to the Envelopes of Gram-Positive Bacteria (2006, background): “pyogenes (group A streptococcus [GAS]) is a gram-positive extracellular human pathogen and is responsible for a wide spectrum of disease, ranging from localized suppurative infections such as pharyngitis to pyoderma to severe systemic illnesses (for example, pneumonia or septicemia) and to serious p”