The dynamics of CD4+ T-cell depletion in HIV disease

By J. McCune. Nature, 2001

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Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4+ T Lymphocytes from Effector Sites in the Gastrointestinal Tract (2004, background): “Some of the possibilities include decreased local proliferation, increased cell death in the effector compartment due to apoptosis or activation-induced cell death (36), reduced homing of cells to the effector site from the periphery after antigen recognition due to either direct cytopathic effects ”
HIV preferentially infects HIV-specific CD4+ T cells (2002, neutral): “*ART, antiretroviral therapy: treated (+), untreated (2).”
Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral-Treated HIV Infection (2009, neutral): “Although HIV replicates within and can result in the destruction of CD4 T cells [1, 2], the mechanisms whereby HIV infection results in CD4 T cell depletion are”