HIV preferentially infects HIV-specific CD4+ T cells

By Daniel C. Douek, J. Brenchley, M. Betts, D. Ambrozak, Brenna J. Hill, Y. Okamoto, J. Casazza, J. Kuruppu, K. Kunstman, Steven Wolinsky and 6 more. Nature, 2002

1,373 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Virology

View Paper: https://www.semanticscholar.org/paper/fc2b42bc7b535fb55b2e9590578f6a3f7f99061a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Daniel C. Douek
2. V. Appay
3. D. Sauce
4. A. Haase
5. Mario Roederer

In Infectious Diseases

1. Daniel C. Douek
2. V. Appay
3. D. Sauce
4. A. Haase
5. A. Khoruts

In Virology

1. Daniel C. Douek
2. V. Appay
3. D. Sauce
4. A. Haase

Citations in the corpus

• Immune activation and inflammation in HIV‐1 infection: causes and consequences (2008, background): “HIVspecific CD4+ T cell responses are usually present at a lower magnitude (ie up to 3% of circulating CD4+ T cells) [30], which may be related to their preferential depletion by the virus [32].”
• CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract (2004, background): “Importantly, as the percentage of infected peripheral blood CD4 T cells is usually 1% in chronic infection (39, 51), it seems unlikely that direct infection of activated CD4 T cells is solely responsible for the death of CCR5 CD4 T cells, and other factors likely contribute.”
• Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production (2013, methodology): “Previously published primer-probe combinations were used for both albumin and HIV-gag amplification (Douek et al., 2002).”