Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells.

By J. Palumbo, K. Kombrinck, A. Drew, Timothy S. Grimes, John H. Kiser, J. Degen, T. Bugge. Blood, 2000

625 citations recorded by the source corpus.

Subfields: Hematology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/2bd98e32234024ced5294272eaa4a2732bb16c49

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In Hematology

1. B. Felding‐Habermann
2. Laurie J. Gay

Citations in the corpus

• Contribution of platelets to tumour metastasis (2011, background): “Treatment with the thrombin inhibitor hiruidin further reduces metastasis in PAR4-null mice, implying a mechanism that involves other thrombin ligands, such as fibrinoge”
• Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. (2005, methodology): “Tumor cell transplantation and histological analysis: B16-BL6 melanoma cells and green fluorescent protein expressing Lewis lung carcinoma cells (LLC) (both C57BL/6 derived tumor cells lines) were grown in vitro and injected into mice as previously described.(9,10) For experimental metastasis assays”