Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.

By J. Palumbo, K. Talmage, J. V. Massari, Christine M La Jeunesse, M. Flick, K. Kombrinck, M. Jiroušková, J. Degen. Blood, 2005

994 citations recorded by the source corpus.

Subfields: Hematology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/068cf77882caa190125e287d5e6fa1d86925dc7a

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Citations in the corpus

Contribution of platelets to tumour metastasis (2011, background): “Nonetheless, there is no change in tumour growth in mice deficient in fibrin, platelet activation or GPVI expression, and there are no overt vascular differences from the wild-type mic”
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics (2015, positive): “Platelets sequester solubilized tumor-associated proteins (Klement et al., 2009) and spliced and unspliced mRNAs (Calverley et al., 2010; Nilsson et al., 2011), whereas platelets do also directly interact with tumor cells (Labelle et al., 2011), neutrophils (Sreeramkumar et al., 2014), circulating N”
Direct Signaling Between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis (2011, background): “This shield protects tumor cells from natural killer cell-mediated lysis (Nieswandt et al., 1999; Palumbo et al., 2005), limits their exposure to shear stress, and promotes their adhesion to the endothelium (Erpenbeck and Scho¨n, 2010; Gay and Felding-Habermann, 2011; Im et al., 2004; Jain et al.,…”
Circulating Platelets as Mediators of Immunity, Inflammation and Thrombosis (2018, background): “In murine studies, tumors coated with platelets become impermeable to NK-cell destruction(79) with fibrinogen involvement.(80) It has been proposed that circulating metastatic cells attract platelets and influence them to release their granule content.”
Platelets at the interface of thrombosis, inflammation, and cancer. (2015, background): “The ability of platelets to protect tumor cells in circulation from the normal immune response, or natural killer cells, is likely to significantly contribute to the metastatic process.(73,74) Further, this platelet cloak protects tumor cells in circulation from extreme shear forces encountered in t”
EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, positive): “This effect can be mediated by soluble factors derived from platelets, including TGFβ and PDGF that inhibit NK cell activity (Labelle and Hynes, 2012), and, quite possibly, by physically shielding cancer cells from NK cells through the formation of protective cloaks around CTCs and the deposition of”