Scaling down imaging: molecular mapping of cancer in mice

By Ralph Weissleder. Nature Reviews. Cancer, 2002

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A review of imaging techniques for systems biology (2008, methodology): “Multi-photon Microscopy [29,38] 15 – 1000 nm Secs Fluorescent proteins, dyes, rhodamine amide, quantum dots Visualization of cell structures”
In Vivo Imaging of β-Galactosidase Activity Using Far Red Fluorescent Switch (2004, background): “In particular, luciferases (3), thymidine kinases (4, 5), and green fluorescent protein (6) have been shown recently to be detectable in vivo at different resolutions, sensitivities, costs, and abilities to quantitate (7).”
Fluorescence molecular tomography resolves protease activity in vivo (2002, background): “More recently, near-infrared targeted fluorochromes, sensing fluorogenic substrates and red-shifted photoproteins with higher tissue penetration have been developed to measure molecular events in vivo in small animal”
Protease degradomics: A new challenge for proteomics (2002, background): “cgi?l=4313">MMP-2 (gelatinase A), cathepsins and caspases have been localized in living tissue”
Molecular imaging in living subjects: seeing fundamental biological processes in a new light. (2003, background): “There are five general areas in which considerable research efforts are ongoing (Weissleder 1999; Weissleder and Mahmood 2001) and will also be necessary in the future to perform in vivo molecular imaging (by seeking answers to the questions in parenthesis): (1) selection of appropriate cellular…”