A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer
By F. D. S. E. Melo, A. Kurtova, J. Harnoss, Noelyn M. Kljavin, J. Hoeck, Jeffrey Hung, Jeffrey E. Anderson, E. Storm, Z. Modrusan, H. Koeppen and 3 more. Nature, 2017
696 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/2b5aeb54ff6aff9bef2a2a196ad746ba4c14d245
How researchers see this paper
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In Molecular Biology
- Simone Brabletz
- Thomas Brabletz
- Marc P. Stemmler
- Harald Schuhwerk
- F. Greten
- S. Grivennikov
- R. Weinberg
- M. Nieto
In Oncology
- S. Grivennikov
- F. Greten
- Simone Brabletz
- Thomas Brabletz
- Harald Schuhwerk
- Marc P. Stemmler
- M. Karin
- R. Weinberg
Citations in the corpus
- Dynamic EMT: a multi‐tool for tumor progression (2021, positive): “…for disease progression, induction of EMT, stemness and metastasis, which is not provided by LGR 5 -negative tumor cells and depletion of Lgr 5 + cells in mice blocks metastasis (de Sousa e Melo et al , 2017 ), though a Lgr 5 - state is detected in circulating CSCs (Fumagalli et al , 2020 ).”
- Inflammation and Cancer: Triggers, Mechanisms and Consequences (2019, background): “…of cancer cell plasticity is through their ability to undergo various states of EMT and MET (Gupta et al., 2019; Pastushenko et al., 2018; Varga and Greten, 2017) and re-establishment of cancer stem cell pool during metastasis or therapy (de Sousa e Melo et al., 2017; Sanchez-Danes et al., 2018).”