Basement membranes: structure, assembly and role in tumour angiogenesis

By Raghu Kalluri. Nature Reviews. Cancer, 2003

1,794 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2b307e96bbf808eeeedf63ebaed51e060e49b69c

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Citations in the corpus

Therapeutic targeting of the tumor microenvironment. (2005, neutral): “Some matrix degrading enzymes such as MMPs can also release antiangio-CANCER F O C U S genic proteins such as endostatin, angiostatin, and tumstatin (Hamano et al., 2003; Kalluri, 2003), which inhibit tumorigene sis.”
Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “1).(15) When the solid tumor grows to a volume of more than 1–2 mm(3), the resources in the surrounding tissue are hard to maintain the tumor growth.”
Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “The composition and structure of the normal interstitium (50, 91, 147, 216, 246, 374) and that of tumors (93, 230, 231, 273, 282, 303, 444) have been covered in several extensive reviews and are thus only briefly described here.”
Regulation of retinal blood flow in health and disease. (2008, background): “Extracellular matrix (ECM) The ECM consists of higher order assemblies of numerous components that are secreted in a cell typespecific manner (Kalluri, 2003; Brown et al., 2006).”
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. (2004, background): “There was a 52% reduction in cell proliferation in JPM-angiogenesis (Carmeliet, 2003; Kalluri, 2003), and interestingly, OEt-treated angiogenic islets (p 0.0001), while proliferationcathepsin B has been shown to directly degrade three major in JPM-OEt-treated tumors was reduced by 28% in…”
Cellular abnormalities of blood vessels as targets in cancer. (2005, background): “Type IV collagen, laminin, fibronectin and heparan sulfate proteoglycan are among the main components [33 ].”
Rapid vascular regrowth in tumors after reversal of VEGF inhibition. (2006, background): “Basement membrane is a binding site for heparan sulfate–binding isoforms of VEGF and other factors that can drive vascular regrowth (25, 52, 53).”
Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. (2011, background): “For instance, normal function of epithelia is critically dependent on the basement membrane, a highly specialised ECM which contains type IV collagen, laminin, types XV and XVIII collagens, perlecan and nidogen (Kalluri 2003).”
Tumors as organs: complex tissues that interface with the entire organism (2010, neutral): “In contrast, fragments with antiangiogenic, and thus tumor-inhibiting, activity are generated from type XVIII and type IV collagens (Kalluri, 2003).”