Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

By Qi Chen, M. Espey, Andrew Y. Sun, Je-Hyuk Lee, M. Krishna, E. Shacter, Peter L. Choyke, Chaya Pooput, K. Kirk, G. Buettner and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2007

689 citations recorded by the source corpus.

Subfields: Epidemiology, Materials Chemistry, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/2b132d3c8892781638842ada0cf50658e6dfa349

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Juan Du
2. Qi Chen
3. M. Espey
4. J. Cullen
5. Andrew Y. Sun
6. Chaya Pooput
7. G. Buettner
8. K. Kirk

Citations in the corpus

• Ascorbic acid: Chemistry, biology and the treatment of cancer (2012, background): “The role of hydrogen peroxide generation and removal In vitro, the toxicity of ascorbate centers on the generation of H2O2 by ascorbate upon its oxidation [9,10,12,163,164].”
• Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice (2008, methodology): “Ascorbate and ascorbate radical concentrations in plasma and microdialysates were determined by HPLC separation with electrochemical detection and electron paramagnetic resonance, respectively, as previously described (5).”
• Vitamin C physiology: the known and the unknown and Goldilocks (2016, neutral): “For example, under some conditions ascorbate radical can be measured in blood and extracellular fluid samples (Chen et al., 2007).”