Mechanisms of specificity in protein phosphorylation
By Jeffrey A. Ubersax, J. Ferrell. Nature reviews. Molecular cell biology, 2007
647 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/2b12dadcee3357cef4605d71e93e616e2479bbbb
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Citations in the corpus
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (2008, background): “Reversible phosphorylation of proteins represents a fundamental and evolutionarily conserved type of posttranslational modification that regulates protein function on the molecular and signal transmission on the cellular level (Blume-Jensen and Hunter, 2001; Ubersax and Ferrell, 2007).”
- Proteomics by mass spectrometry: approaches, advances, and applications. (2009, background): “Protein kinases control every basic cellular process, including metabolism, growth, division, differentiation, motility, organelle trafficking, immunity, learning, and memory via regulated protein phosphorylation (196).”
- DOCKSTRING: Easy Molecular Docking Yields Better Benchmarks for Ligand Design (2021, neutral): “96 However, from a medicinal standpoint, their structural similarity makes it challenging to design selective inhibitors.”
- Rewiring the specificity of two-component signal transduction systems. (2008, neutral): “Cells use a variety of mechanisms to enforce the specificity of related, but distinct, signaling pathways (Schwartz and Madhani, 2004; Ubersax and Ferrell, 2007).”
- Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling (2013, background): “Reconstitution and quantitative analysis of the interaction of Bub1–Bub3 with P-MELT Bub1 binds Bub3 through a conserved Bub3-binding domain (Taylor and McKeon, 1997) that is often also referred to as GLEBS motif (Bailer et al., 1998; Wang et al., 2001) (Figure 1A).”
- Linear Motif Atlas for Phosphorylation-Dependent Signaling (2008, background): “The specificity of many kinases is provided in part through the recognition of binding motifs other than those containing the phosphorylation site itself; as an example, MAPKs typically bind short docking motifs within their substrates ( 12 , 39 ).”