Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

By M. Jordan, A. Boesteanu, A. J. Reed, Andria L. Petrone, Andrea E. Holenbeck, M. Lerman, A. Naji, A. Caton. Nature Immunology, 2001

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Subfields: Immunology

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Pathogen-specific T Regulatory 1 Cells Induced in the Respiratory Tract by a Bacterial Molecule that Stimulates Interleukin 10 Production by Dendritic Cells (2002, background): “CD4 CD25 regulatory T cells, which represent 5–10% of CD4 T cells from spleen and lymph nodes of normal mice, can suppress organ-specific autoimmune disease in mice (29, 30).”
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. (2012, background): “In contrast, Foxp3 expression in developing thymocytes appears to depend chiefly on the intensity of TCR stimulation (Jordan et al., 2001), and is rapidly induced after TCR stimulation.”
CD4+CD25+ suppressor T cells: more questions than answers (2002, positive): “A test of this hypothesis was carried out by Jordan et al.(46) by crossing TCR-transgenic mice that expressed a receptor specific for influenza-virus haemagglutinin with transgenic mice that expressed the antigen.”