Why do we age?

By Thomas B. L. Kirkwood, S. Austad. Nature, 2000

1,782 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/2aa946192a1000fb2cf4448abc462785f4d98fdc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. C. Kenyon
2. J. Campisi
3. R. Ricklefs
4. A. Bourke
5. F. d’Adda di Fagagna
6. J. Ahringer
7. A. Brunet
8. E. L. Greer

In Endocrine and Autonomic Systems

1. R. Ricklefs
2. A. Brunet
3. A. Bourke
4. E. L. Greer
5. D. Nussey
6. J. Campisi
7. J. Ahringer
8. C. Kenyon

In Physiology

1. J. Campisi
2. P. Desprez
3. F. d’Adda di Fagagna
4. F. Rodier
5. C. Patil
6. Jean-Philippe Coppé
7. D. Peeper
8. T. Kuilman

Citations in the corpus

• Ageing and reproductive effort in male moose under variable levels of intrasexual competition (2005, background): “Both evolutionary-based hypotheses of senescence, the mutation‐accumulation hypothesis (Medawar 1946; Edney & Gill 1968) and the antagonistic pleiotropy hypothesis (Medawar 1946; Williams 1957; Hamilton 1966; Rose 1991) as well as the disposable soma theory (review in Kirkwood & Austad 2000 ), pred”
• Senescence in natural populations of animals: Widespread evidence and its implications for bio-gerontology (2012, methodology): “As already discussed, work on laboratory model systems generally supports these ‘life history’ theories of aging (Table 1, Kirkwood and Austad, 2000; Partridge and Barton, 1996).”
• Climate‐dependent allocation of resources to secondary sexual traits in red deer (2005, background): “Decline in performance traits with age after prime-age (i.e. senescence; Kirkwood and Austad 2000), has been documented for a number of ungulates for body weight (Mysterud et al.”
• Cellular senescence: when bad things happen to good cells (2007, background): “This concept — that a process can be beneficial to young organisms but harmful to old organisms — is the essence of antagonistic pleiotropy , an important evolutionary theory of agein”
• The evolutionary ecology of senescence (2008, background): “There is some empirical evidence in support of each ( Kirkwood & Austad 2000 ) and Wilson et al. (2008) provide a short review of the testing of these hypotheses.”
• Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor (2008, background): “]. The apparent paradox of contributing to both tumor suppression and aging is consistent with an evolutionary theory of aging, termed antagonistic pleiotropy [”
• Life history correlates of oxidative damage in a free‐living mammal population (2009, background): “This mechanistic theory of ageing complements the disposable soma theory of ageing, which states that senescence occurs due to an adaptive failure of repair and replacement mechanisms as natural selection weakens with age (Kirkwood & Rose 1991; Kirkwood & Austad 2000 ).”
• Accumulation of senescent cells in mitotic tissue of aging primates. (2007, background): “Keywords Senescence; telomeres; DNA damage; aging; p16; p21 Introduction Organismal aging is accompanied by a progressive loss of tissue structure and function, however the cause of tissue degeneration remains poorly understood (Kirkwood and Austad, 2000).”
• Increased susceptibility to oxidative stress as a proximate cost of reproduction (2004, positive): “According to the free radical theory of ageing, the accumulation of ROS-induced damages through time would be the causal agent of the age-associated decline in performance (Finkel & Holbrook 2000; Kirkwood & Austad 2000).”