Nuclear receptor expression links the circadian clock to metabolism.

By Xiaoyong Yang, M. Downes, R. Yu, A. Bookout, Weimin He, Martin Straume, D. Mangelsdorf, R. Evans. Cell, 2006

958 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/2a8dcba7bad1075b7e785b914773bc76bd83263b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. J. Takahashi
2. C. Green
3. C. H. Ko
4. J. Mohawk
5. A. Jetten
6. Erin L. McDearmon
7. Heekyung Hong

In Molecular Biology

1. A. Jetten
2. R. Evans
3. Bart Staels
4. C. H. Ko
5. J. Takahashi
6. D. Mangelsdorf

Citations in the corpus

• Hepatocyte-specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation (2009, background): “Under normal physiological conditions in mice, PPARa levels in the liver peak in the late afternoon and decrease immediately after food intake (Yang et al., 2006), (http://www.”
• The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “Recent gene expression analysis of the nuclear receptor family has shown that of the 49 nuclear receptors in mice, 28 of them display tissue-specific circadian rhythms in various tissue”
• Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “RORγ exhibits an oscillatory expression pattern in liver, brown adipose tissue, and kidney, but not in skeletal muscle and thymus [Guillaumond et al., 2005; Jetten and Joo, 2006; Kang et al., 2007; Ueda et al., 2002b; Ueda et al., 2005;Yang et al., 2006].”
• CENTRAL AND PERIPHERAL CIRCADIAN CLOCKS IN MAMMALS (2012, background): “The cell-autonomous clock is ubiquitous, and almost every cell in the body contains a circadian clock (Balsalobre et al. 1998, Nagoshi et al. 2004, Welsh et al. 2004, Yoo et al. 2004).”
• Role of bile acids and bile acid receptors in metabolic regulation. (2009, background): “White adipose FXR and FXR expression is also subjected to circadian variation (352).”
• Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006, methodology): “The supplemental poster shows a graphical representation of the anatomical and circadian expression profiles of the 49 mouse NRs from this work and the companion paper by Yang et al. (2006).”