Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice

By E. Traggiai, L. Chicha, L. Mazzucchelli, L. Bronz, J. Piffaretti, A. Lanzavecchia, M. Manz. Science, 2004

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Humanized mice in translational biomedical research (2007, background): “The third breakthrough was the humanization of immunodeficient mice homozygous for targeted mutations at the interleukin-2 receptor (IL-2R) γ-chain locus ( Il2rg ; also known as the common cytokine-receptor γ-chain, γc”
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo (2009, neutral): “:3) c (cid:2) / (cid:2) mice develop into mature myeloid and lymphoid cells ( 15, 16 ).”
Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice (2007, background): “Rag2 −/− /Il2rg −/− mice have been reported to be excellent recipients of human hematopoietic xenograft”
Human Lymphoid and Myeloid Cell Development in NOD/LtSz-scid IL2Rγnull Mice Engrafted with Mobilized Human Hemopoietic Stem Cells 12 (2004, methodology): “These mice support high levels of engraftment with human UMB HSC that develop into a functional adaptive immune system (20).”