The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase

By E. Six, Delphine Ndiaye, Y. Laâbi, C. Brou, Neetu Gupta-Rossi, A. Israël, F. Logeat. Proceedings of the National Academy of Sciences of the United States of America, 2003

231 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology, Ocean Engineering

View Paper: https://www.semanticscholar.org/paper/2a23de7947c3d45d534408c0357a14e0f7e462a0

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In Molecular Biology

1. M. Wicha
2. M. Handsley
3. Kyle W. Jackson
4. D. Edwards
5. M. Kawamura
6. W. Abdallah
7. C. Pennington
8. G. Dontu

Citations in the corpus

• The ADAM metalloproteinases (2008, background): “It is now clear that these proteases regulate cell phenotype and behaviour by ectodomain shedding and RIPping, and that separately from their proteolytic functions, many influence cell-cell communication via adhesive interactions.”
• The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. (2009, unknown): “For the same reason, Jagged1 reverse signaling, a process that would involve ligand cleavage and release of a cytoplasmic, Notch-inhibiting fragment (LaVoie and Selkoe, 2003; Six et al., 2003) cannot explain our findings.”
• Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells (2004, background): “The Notch proteins, represented by four homologs in mammals (Notch1–Notch4), interact with a number of surface-bound or secreted ligands (Delta-like 1, Delta-like 3, Delta-like 4, Jagged 1 and Jagged 2) [ 8-10 ].”