Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down.

By J. Callicott, Venkata S. Mattay, Beth A. Verchinski, S. Marenco, Michael Egan, Daniel R. Weinberger. American Journal of Psychiatry, 2003

712 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/2a023fe4a308cf521c2ecd548495c3533ea4339f

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In Cognitive Neuroscience

In Psychiatry and Mental health

Citations in the corpus

Developmental regulation of human cortex transcription and its clinical relevance at base resolution (2014, neutral): “Lastly, we observe that the majority of PGC risk loci associated with schizophrenia 27 contain expressed sequence in the DLPFC, one of the brain regions most consistently implicated in schizophrenia 32 .”
Dysfunction of ventral striatal reward prediction in schizophrenia (2006, background): “It is known that performance differences between patients and controls can confound interpretation of imaging data (Callicott et al., 2003).”
Cognitive fitness of cost-efficient brain functional networks (2009, background): “On the hypothesis that brain network organization has evolved by optimizing competitive selection criteria of cost and efficiency, we predicted that individual differences in cognitive performance should be related to variability in cost efficiency of human brain functional networks (12, 13).”
Meta-analysis of 41 Functional Neuroimaging Studies of Executive Function in Schizophrenia (2009, background): “Forty-one studies published prior to February 2007 met these criteria (Table 1).(3,5,13-51) Study design features are indicated in Table 1, including clinical characteristics like illness duration and symptom severity; sex ratio among the patient group; medication status; block vs event-related desi”
Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. (2004, background): “hyperactivation); alternatively, greater noise might manifest as a loss of activation if the cortical network becomes too unstable and task performance degrades [1, 27 ].”
Cortical inhibitory neurons and schizophrenia (2005, background): “In addition, under conditions in which individuals with schizophrenia perform normally on working memory tasks, activity in the DLPFC can be increased, which indicates that the DLPFC operates less efficientl”