Predictive value of noninvasivelydetermined endothelial dysfunction for long-term cardiovascular events inpatients with peripheral vascular disease

By N. Gokce, J. Keaney, L. Hunter, M. Watkins, Z. Nedeljkovic, J. Menzoian, J. Vita. 2003

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Health effects of particulate air pollution: A review of epidemiological evidence (2011, background): “Impaired endothelial function is associated with nearly all known cardiovascular risk factors (Ganz & Vita, 2003; Libby et al., 2002; Ross, 1999; Vita & Keaney, Jr., 2002) and is predictive of future cardiovascular events (Gokce et al., 2002; Gokce et al., 2003; Heitzer et al., 2001).”
The relationship between shear stress and flow‐mediated dilatation: implications for the assessment of endothelial function (2005, background): “Brachial artery FMD is emerging as an independent predictor of future cardiac events (Gokce et al. 2002, 2003; Widlansky et al. 2003).”
Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis (2010, background): “In fact, some studies have found the associations to be weak or non-significant after multivariate adjustment [ 17 , 23, 24].”
The Endothelium and Its Role in Regulating Vascular Tone (2010, background): “In addition, assessments of endothelial function are good predictors of future cardiac events in individuals at risk of CVD and those with established CVD [99, 100], and ED is common in individuals with CVD risk factors [101].”