Computerized microfluidic cell culture using elastomeric channels and Braille displays.

By W. Gu, Xiaoyue Zhu, N. Futai, Brenda S. Cho, Shuichi Takayama. Proceedings of the National Academy of Sciences of the United States of America, 2004

403 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/29f31e90cb16214f314369506db3c78396727732

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Citations in the corpus

Microvalves and Micropumps for BioMEMS (2011, methodology): “Flow rates up to ~600 nL/min were observed, with the maximum flow rate limited by the refresh rate of the Braille pins, which is about 120 ms [52].”
Lab-on-a-chip: microfluidics in drug discovery (2006, background): “Moreover, there have been promising advances in the design of programmable pumps and valves that could be used to precisely control liquid supply in cell culture experiment”
From Three-Dimensional Cell Culture to Organs-on-Chips (2011, methodology): “A self-contained microcirculating cell-culture system was created using a commercial Braille display composed of a computer-controlled array of piezo-electric pins that actuate microﬂuidic pumps and valves through localized elastic deformation of the PDMS channels [40,41].”
Microfluidic large-scale integration: the evolution of design rules for biological automation. (2007, methodology): “This technology enables hundreds of assays to be performed in parallel with multiple reagents in an automated manner and has been used in applications such as protein crystallography (12–14), genetic analysis (26), amino acid analysis (36), high-throughput screening (42), bioreactors (10), chemical ”
Biology-inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing (2016, unknown): “They began with single cell type cultures of different organ specificity, such as endothelial cells (Young and Simmons, 2010), myoblasts (Gu et al., 2004),”