Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast.

By Chang Hun Lee, Ho Joon Shin, I. Cho, Young-Mi Kang, In Ae Kim, K. Park, Jung-Woog Shin. Biomaterials, 2005

642 citations recorded by the source corpus.

Subfields: Biomaterials, Biomedical Engineering, Surfaces, Coatings and Films

View Paper: https://www.semanticscholar.org/paper/29e3f3e9236c247a93ed201b7539ee573c399c00

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In Biomaterials

In Biomedical Engineering

In Surfaces, Coatings and Films

Seeram Ramakrishna

Citations in the corpus

Nanofibers and their applications in tissue engineering (2006, background): “In addition, the authors also studied the effect of direction of mechanical stimuli on the ECM produced by HLFs.”
The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration (2011, positive): “Importantly, collagen per DNA was not statistically different between aligned and non aligned scaffolds, suggesting differential organization of the existing ECM [162], although some studies have also reported that scaffold alignment serves to increase matrix deposition [166,167].”
Electrospun poly(epsilon-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering. (2008, methodology): “Aligned PCL and PCL/gelatin nanofibers fabricated by electrospinning process provided a controlled orientation of nerve cells proving that the aligned electrospun nanofibers are capable of controlling the orientation of neurons by a mechanism called contact guidance [5,16–20].”
Potential of Nanofiber Matrix as Tissue-Engineering Scaffolds (2005, positive): “74 cultured human ligament fibroblasts on aligned polyurethane (PU) nanofiber and evaluated cell orientation and ECM production.”
Local force and geometry sensing regulate cell functions (2006, background): “Furthermore, the nanofibre alignment and direction of mechanical strain affect the ECM productio”
Electrospinning: applications in drug delivery and tissue engineering. (2008, background): “Tissue applications The process of electrospinning has been found to have great potential in the engineering of a number of tissues including: vasculature [23,52,83e87], bone [48,65,67,88e90], neural [42,49], and tendon/ligament [91,92].”
The regulation of tendon stem cell differentiation by the alignment of nanofibers. (2010, background): “The aligned nanofibers are suitable for ligament cell proliferation and orientation under a mechanical stimulus [39], and scaffolds with an aligned nanotopography are effective in enhancing axon extrusion from neuronal stem cells [24,40].”