Nanofibers and their applications in tissue engineering

By R. Vasita, D. Katti. International Journal of Nanomedicine, 2006

931 citations recorded by the source corpus.

Developing scaffolds that mimic the architecture of tissue at the nanoscale is one of the major challenges in the field of tissue engineering. The development of nanofibers has greatly enhanced the scope for fabricating scaffolds that can potentially meet this challenge. Currently, there are three techniques available for the synthesis of nanofibers: electrospinning, self-assembly, and phase separation. Of these techniques, electrospinning is the most widely studied technique and has also demonstrated the most promising results in terms of tissue engineering applications. The availability of a wide range of natural and synthetic biomaterials has broadened the scope for development of nanofibrous scaffolds, especially using the electrospinning technique. The three dimensional synthetic biodegradable scaffolds designed using nanofibers serve as an excellent framework for cell adhesion, proliferation, and differentiation. Therefore, nanofibers, irrespective of their method of synthesis, have been used as scaffolds for musculoskeletal tissue engineering (including bone, cartilage, ligament, and skeletal muscle), skin tissue engineering, vascular tissue engineering, neural tissue engineering, and as carriers for the controlled delivery of drugs, proteins, and DNA. This review summarizes the currently available techniques for nanofiber synthesis and discusses the use of nanofibers in tissue engineering and drug delivery applications.

Subfields: Biomaterials, Biomedical Engineering, Surgery

View Paper: https://www.semanticscholar.org/paper/640f8a496eed93d995676f549ef98748ea1fd77b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. D. Kumar
2. R. Nayak
3. Lyndon Arnold
4. I. L. Kyratzis
5. M. Chavali
6. Brahatheeswaran Dhandayuthapani
7. Y. Yoshida
8. T. Maekawa

In Biomedical Engineering

1. D. Kumar
2. R. Nayak
3. Lyndon Arnold
4. I. L. Kyratzis
5. M. Chavali
6. Brahatheeswaran Dhandayuthapani
7. Y. Yoshida
8. T. Maekawa

In Surgery

1. D. Kumar
2. Brahatheeswaran Dhandayuthapani
3. Y. Yoshida
4. T. Maekawa

Citations in the corpus

• POLYMERIC SCAFFOLDS IN TISSUE ENGINEERING APPLICATION: A REVIEW (2011, background): “Developing scaffolds that mimic the architecture of tissue at the nanoscale is one of the most important challenges in the field of tissue engineering [168].”
• Recent advances in biomaterials for 3D scaffolds: A review (2019, background): “as scaffolds for skin, cartilage, ligament, bone, muscle, vein and vehicles for drugs, DNA and proteins [20].”
• Recent advances in nanofibre fabrication techniques (2012, methodology): “In addition to the above mentioned techniques, several other innovative methods such as template synthesis, self-assembly, phase-separation, drawing have been reported for nanofibre fabrication.(107) In template synthesis, nanofibres of polymers,metals, semiconductors and ceramics are formed within ”
• A comprehensive review summarizing the effect of electrospinning parameters and potential applications of nanofibers in biomedical and biotechnology (2015, neutral): “Arabian Journal of Chemistry (2015), http:/ past decade, nanofibers systems have been targeted for the preparation of scaffolds for tissue engineering (Vasita and Katti, 2006).”