Gene map of the extended human MHC

By R. Horton, L. Wilming, V. Rand, Ruth C. Lovering, E. Bruford, V. Khodiyar, M. Lush, S. Povey, C. Conover, Talbot Jr and 5 more. Nature reviews genetics, 2004

1,195 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/29dc87efc51ee50a4a858e4831d0f34674a12c93

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In Immunology

1. Steven G. E. Marsh
2. James Robinson
3. Peter Parham
4. Rodrigo Lopez
5. Robert M. Plenge
6. David A. Hafler

Citations in the corpus

• Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis (2008, positive): “6 Mb of the genome, has been recently established by the finding that linkage disequilibrium (LD) and MHC-related genes exist outside the classically defined locus [4].”
• Tissue-Specific Differences in Human Transfer RNA Expression (2006, background): “For example, a high expression level of tRNA in this region may facilitate high expression of histocompatibility complex genes following a signaling event [29].”
• The IPD-IMGT/HLA Database (2022, background): “3 region on the short arm of chromosome 6 (15).”
• Mapping complex disease traits with global gene expression (2009, background): “Analysis of eQTLs in the MHC locus is of particular interest for studies of diseases in which infection and autoimmunity is a major componen”
• Gender differences in autoimmune disease. (2014, neutral): “, 2013) amongst many others (Horton et al., 2004).”
• Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens (2013, background): “The HLA genes encode cell-surface proteins that present antigen peptides to the host immune system, and are among the most polymorphic genes in the human genome [1].”
• A high resolution HLA and SNP haplotype map for disease association studies in the extended human MHC (2006, background): “Major efforts have therefore been directed at cataloguing the gene and variation content of the entire MH”
• The IPD and IMGT/HLA database: allele variant databases (2014, background): “The MHC is one of the most complex and polymorphic regions of the human genome, with in excess of 220 genes (2).”
• Discovery and Validation of a Prostate Cancer Genomic Classifier that Predicts Early Metastasis Following Radical Prostatectomy (2013, background): “The genomic locus containing gene TSBP (also known as C6orf10) is located in the classical Class II block of the Major Histocompatibility Complex (MHC) region in chromosome 6 [67,68].”
• The IMGT/HLA database (2008, methodology): “Further data have been submitted following large-scale genome sequencing projects (1,28).”
• Major Histocompatibility Complex Genomics and Human Disease (2013, neutral): “Examples of the role of MHC genes in immune function are illustrated, including the key role in antigen presentation and processing as well as inflammation, the complement cascade, and stress response (51).”