The IPD and IMGT/HLA database: allele variant databases
By James Robinson, J. Halliwell, J. Hayhurst, Paul Flicek, Peter Parham, Steven G. E. Marsh. Nucleic Acids Res., 2014
1,751 citations recorded by the source corpus.
The Immuno Polymorphism Database (IPD) was developed to provide a centralized system for the study of polymorphism in genes of the immune system. Through the IPD project we have established a central platform for the curation and publication of locus-specific databases involved either directly or related to the function of the Major Histocompatibility Complex in a number of different species. We have collaborated with specialist groups or nomenclature committees that curate the individual sections before they are submitted to IPD for online publication. IPD consists of five core databases, with the IMGT/HLA Database as the primary database. Through the work of the various nomenclature committees, the HLA Informatics Group and in collaboration with the European Bioinformatics Institute we are able to provide public access to this data through the website http://www.ebi.ac.uk/ipd/. The IPD project continues to develop with new tools being added to address scientific developments, such as Next Generation Sequencing, and to address user feedback and requests. Regular updates to the website ensure that new and confirmatory sequences are dispersed to the immunogenetics community, and the wider research and clinical communities.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/aca92bbbe7ebc8b6b0f272aca209ac5a027222bd
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In Immunology
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Citations in the corpus
- Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction (2017, background): “The HLA genes are the most polymorphic genes across the human population; more than 10,000 HLA class I allele variants have been identified to date (Robinson et al., 2015).”
- NetMHCpan-3.0; improved prediction of binding to MHC class I molecules integrating information from multiple receptor and peptide length datasets (2016, background): “This aspect becomes extremely important if we consider the huge polymorphism of MHC genes, with several thousand allelic variants identified to date in the HLA loci [4].”
- The EMBL-EBI search and sequence analysis tools APIs in 2019 (2019, methodology): “IPD-HMC, IPD-KIR and IPD-IHMGT/HLA (26) databases were also updated so that nucleotide sequences are split into CDS (coding sequence) and Genomic sequences.”