The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo.
By Christer Atuma, V. Strugala, A. Allen, L. Holm. American Journal of Physiology - Gastrointestinal and Liver Physiology, 2001
1,030 citations recorded by the source corpus.
Subfields: Gastroenterology, Plant Science, Surgery
View Paper: https://www.semanticscholar.org/paper/299b7999678eb84659e559d8723a6a96b4cee53b
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Citations in the corpus
- Perspectives on mucus secretion in reef corals (2005, background): “More recent in vivo observations of human intestinal mucus suggest, however, an innermost layer of firmly adherent gel and an outer layer of sloppy constituency in this secretion (Atuma et al. 2001).”
- Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress (2010, background): “The outer loosely adherent mucus layer formed by proteolytic and glycosidic degradation of highly polymerized gel-like MUC2 mucin was similar in thickness in stomach and jejunum, but markedly increased in ileum, and thickest in colon (Table 1) [36].”
- Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa (2010, background): “The depth of the mucus layer varies with the region of the intestinal tract, but is thickest in the colon and rectum, reaching over 800 mm in rodents [25].”
- Intestinal microbiota in human health and disease: the impact of probiotics (2011, background): “…organisation of the mucus layers varies amongst the different parts of the GI tract, as it has been observed that the mucus layers in the stomach and the colon are well defined, in contrast to the small intestine where the mucus is less evenly distributed (Atuma et al. 2001; Johansson et al. 2010).”
- The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system (2014, neutral): “The inner mucus layer is ‘firmly’ attached to the epithelium and about 50 lm thick in distal colon of mice and 200–300 lm thick in humans (2, 6, 36).”
- Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? (2008, background): “There is considerable controversy with respect to the importance of the mucus-bicarbonate “barrier” in mucosal defense which centers on three main aspects: 1) whether or not the thickness of surface mucus is important for protecting the epithelium from the damaging effects of acid (22, 33), 2) wheth”
- Probiotic Lactic Acid Bacteria: A Review (2014, background): “The thickness and physical state of the intestinal mucus layer [34] [35] and its response to orally consumed lactobacilli [36] [37] are important in the immune response.”
- The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions (2010, methodology): “Two Mucus Layers in Colon The thickness of the inner mucus layer in distal colon has been estimated to be approximately 50 μminmice and 100μmin rat (13, 15, 16).”