A temperature accelerated method for sampling free energy and determining reaction pathways in rare events simulations

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The future of molecular dynamics simulations in drug discovery (2011, background): “Several distinct, atomistic approaches aim to accelerate the still-insufﬁcient sampling of protein conformational states, for example metadynamics [48], accelerated MD [49], and temperature accelerated MD [50].”
Enhanced Sampling in Molecular Dynamics Using Metadynamics, Replica-Exchange, and Temperature-Acceleration (2013, methodology): “Force Algorithm [6], Temperature-Accelerated MD [7] and Metadynamics [8].”
Enhanced Sampling Methods for Molecular Dynamics Simulations [Article v1.0] (2022, background): “In the “single sweep" method, TAMD is used to estimate local free energy gradients, followed by estimation of the free energy surface [344].”
The heterogeneous multiscale method* (2012, unknown): “…especially handy in situations where the values taken by the fast variables are constrained by the slow variables, which arises in molecular dynamics simulations, for example (for applications in this context see, e.g., Maragliano and Vanden-Eijnden (2006, 2007), Abrams and Vanden-Eijnden (2010)).”