Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity.

By Robert Dantzer. European Journal of Pharmacology, 2004

739 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/29247e964884954fae4f8f0d61fa97d519dae358

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. Andrew H. Miller
2. Charles L Raison
3. L. Capuron
4. T. Pace
5. Fang Hu
6. V. Perry
7. C. Holmes
8. C. Cunningham

In Immunology

1. C. Cunningham
2. P. Calder
3. V. Perry
4. C. Holmes
5. Bostjan Seruga
6. I. Tannock
7. Andrew H. Miller
8. R. Ransohoff

In Neurology

1. C. Cunningham
2. V. Perry
3. C. Holmes
4. P. Calder
5. P. Vaupel
6. Charles L Raison
7. L. Capuron
8. Andrew H. Miller

Citations in the corpus

• Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. (2007, background): “This syndrome shares many features with major depression including alterations in mood, neurovegetative function, and cognition (Dantzer, 2004).”
• Cytokines and their relationship to the symptoms and outcome of cancer (2008, background): “The best example of the communication between peripheral cytokines and the brain is 'sickness behaviour', which is induced by peripheral infection and mediated by temporarily expressed pro-inflammatory cytokines in the periphery and in the brai”
• Cytokines sing the blues: inflammation and the pathogenesis of depression. (2006, background): “For example, studies in laboratory animals provide compelling evidence that inflammatory cytokines induce a syndrome of sickness behavior that has many overlapping features with major depression, including anhedonia (an inabililty to experience pleasure), anorexia, impaired sleep and reduced locomot”
• Burnout and risk of cardiovascular disease: evidence, possible causal paths, and promising research directions. (2006, background): “Compelling evidence indicates such cytokines communicate with the brain to produce anxiety, depression, learned helplessness, and cognitive disturbances (Dantzer, 2004; Maier & Watkins, 1998; Reichenberg et al., 2001; Weaver et al., 2002; Wilson, Finch, & Cohen, 2002).”
• Systemic infections and inflammation affect chronic neurodegeneration (2007, background): “Three major routes of communication are known, all of which lead to the synthesis of cytokines and inflammatory mediators in the brain parenchyma, which are typically associated with tissue injur”
• ESPEN expert group recommendations for action against cancer-related malnutrition. (2017, background): “In fact, there is a consistent association between symptoms, the presence of inflammatory markers, and upregulated immune responses (Figure 2) [26-30].”