Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages

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Body barrier surveillance by epidermal gammadelta TCR (2012, positive): “Stress recognition can also be mediated through the NK cell family receptor NKG2D, which binds the stress-upregulated proteins of the Rae family 1, 10, 11 .”
NK cells and cancer immunosurveillance (2008, background): “…comprise members of the GPI-anchored Rae-1 family of proteins (Rae1a, b, g, d, and e) as well as the transmembranous ligands H60 (Cerwenka et al., 2000; Diefenbach et al., 2000) and murine UL16-binding protein–like transcript 1 (Mult1) (Carayannopoulos et al., 2002a; Diefenbach et al., 2003).”
Regulation of ligands for the NKG2D activating receptor (2013, background): “Furthermore, some of the ligands are transmembrane proteins, while others are glycosylphosphatidylinositol (GPI)-linked (2, 7, 30) (Figure 1).”
Cutting Edge: Down-Regulation of MICA on Human Tumors by Proteolytic Shedding (2002, background): “In the mouse, which lacks MHC class I chain (MIC) genes, a family of proteins structurally related to ULBP, the retinoic acidearly (RAE-1) molecules function as ligands for NKG2D (13, 14).”
NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. (2008, background): “, 1999), tumor cell lines (Cerwenka et al., 2000; Diefenbach et al., 2000; Pende et al., 2001; Pende et al., 2002), and in some infected cells (Gourzi et al.”