Click Chemistry, A Powerful Tool for Pharmaceutical Sciences
By Christopher D. Hein, Xin-ming Liu, Dong Wang. Pharmaceutical Research, 2008
736 citations recorded by the source corpus.
Click chemistry refers to a group of reactions that are fast, simple to use, easy to purify, versatile, regiospecific, and give high product yields. While there are a number of reactions that fulfill the criteria, the Huisgen 1,3-dipolar cycloaddition of azides and terminal alkynes has emerged as the frontrunner. It has found applications in a wide variety of research areas, including materials sciences, polymer chemistry, and pharmaceutical sciences. In this manuscript, important aspects of the Huisgen cycloaddition will be reviewed, along with some of its many pharmaceutical applications. Bioconjugation, nanoparticle surface modification, and pharmaceutical-related polymer chemistry will all be covered. Limitations of the reaction will also be discussed.
Subfields: Molecular Biology, Organic Chemistry, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/28d536de93f2bd84243ae235b4cd258fb48d88ea
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In Molecular Biology
In Organic Chemistry
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy (2012, background): “However, the Cu(I) catalyst, needed to drive the reaction, can cause toxicity, such as hepatitis, neurological disorders, kidney disease, or Alzheimer’s disease in vivo [158].”
- Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging (2009, background): “Excess Cu consumption has been linked to a number of disorders such hepatitis, neurological disorders, kidney diseases, and Alzheimer’s disease [198].”