Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

By T. Gebhardt, L. Wakim, L. Eidsmo, P. Reading, W. Heath, F. Carbone. Nature Immunology, 2009

1,135 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/28a261a16ffb47336704d3a04810ef458b212f23

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Citations in the corpus

Intraepithelial type 1 innate lymphoid cells are a unique subset of cytokine responsive interferon-γ-producing cells (2013, neutral): “…CD8 T (Trm) cells, which are virusspecific cells that persist in the mucosae and skin after the resolution of viral infections (Casey et al., 2012; Gebhardt et al., 2009; Jiang et al., 2012; Sathaliyawala et al., 2013; Wakim Immunity 38, 1–13, April 18, 2013 ª2013 Elsevier Inc. 1 (legend…”
Dendritic-cell-based therapeutic cancer vaccines. (2013, background): “A third category, i.e., tissue-resident memory T cells, has been recently identified (Jiang et al., 2012;Mueller et al., 2013) and shown to be superior to circulating memory T cells at providing rapid long-term protection against reinfection (Gebhardt et al., 2009; Jiang et al., 2012).”
Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation (2012, methodology): “Ganglia were digested for 90 min in collagenase type 3 (3 mg/mL) as described (19).”
Quantifying memory CD8 T cells reveals regionalization of immunosurveillance (2015, background): “These observations revise perceptions of immunosurveillance and may help explain why frontline memory CD8 T cell populations can rapidly detect infections in barrier tissues (Gebhardt et al., 2009; Jiang et al., 2012; Shin and Iwasaki, 2012; Teijaro et al., 2011; Wu et al., 2014).”
A vaccine strategy protects against genital herpes by establishing local memory T cells (2012, neutral): “Disease was monitored daily and scored as follows: (0) no disease; (1) genital inflammation; (2) genital lesions and hair loss; (3) hunched posture and ruffled fur; (4) hind limb paralysis; and (5) premoribund(28).”
Tissue-Resident Memory T Cells (2014, background): “However, NLT-derived memory T cells also express many markers not shared by any circulating population of memory T cells within blood (Casey et al., 2012; Gebhardt et al., 2009; Hawke et al., 1998; Hofmann and Pircher, 2011; Jiang et al., 2012; Masopust et al., 2006; Ray et al., 2004).”
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets (2012, positive): “Studies in mice have revealed an important role for tissue-resident memory CD4 andCD8 T cells in protective immunity to site-specific pathogens in the lung and skin (Gebhardt et al., 2009; Liu et al., 2010; Teijaro et al., 2011) and that mucosal sites such as lung and intestine contain tissueretaine”
Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity (2012, background): “T RM cells have now been identified in the skin, gut, lung and brain in murine model”
Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “In any case, TRM appear uniquely positioned in the peripheral tissue to quickly enact effector functions and provide protection from reinfection or reactivation of latent virus (214, 215).”
Antigen independent differentiation and maintenance of effector-like resident memory T cells in tissues (2012, background): “In addition to lacking CD62L expression, TRM populations are characterized by CD69 expression and typically CD103 expression (15, 16, 18, 19, 23).”