S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth
By N. V. Dorrello, A. Peschiaroli, D. Guardavaccaro, N. Colburn, N. Sherman, M. Pagano. Science, 2006
661 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/28a2590ff2c2785ec578df0559bc328c55079928
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In Molecular Biology
- David M. Sabatini
- R. A. Saxton
- Nahum Sonenberg
- Arkaitz Carracedo
- Timothy R. Peterson
- P. Pandolfi
- Shomit Sengupta
- D. Guertin
Citations in the corpus
- A Novel Function of eIF2α Kinases as Inducers of the Phosphoinositide-3 Kinase Signaling Pathway (2007, background): “Activation of translation initiation factors eIF4E, eIF4G, eIF4A, and eIF4B is regulated directly or indirectly by FRAP/mTOR (Gingras et al., 2001b; Shahbazian et al., 2006; Dorrello et al., 2006).”
- The PTEN–PI3K pathway: of feedbacks and cross-talks (2008, background): “mTORC1 phosphorylates and activates S6 kinases 1 and 2 (Guertin and Sabatini, 2007), which in turn activates protein translation and ribosome biogenesis through phosphorylation of different substrates in addition to ribosomal protein S6, including PDCD4, eEF2 kinase and eIF4B (Wang et al., 2001; Rau”
- Translational Control in Cancer. (2018, neutral): “1) by phosphorylating the 4E-BPs to allow eIF4F complex formation, and ribosomal protein S6 kinase (S6K), which, in turn, regulates eIF4A via PDCD4 and eIF4B, as well as eEF2K, to alleviate inhibition of elongation (Raught et al. 2004; Dorrello et al. 2006; Faller et al. 2015; Proud 2018).”
- Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress (2010, background): “The S6K1 substrate, PDCD4, inhibits translational initiation under serum withdrawal and is lost in aggressive carcinomas (Carayol et al., 2008; Dorrello et al., 2006).”
- mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. (2013, background): “…components of the translational machinery and associated factors such as ribosomal protein S6, eIF4B, and PDCD4 (Banerjee et al., 1990; Dorrello et al., 2006; Kozma et al., 1990; Shahbazian et al., 2006). mTORC1 also controls energy metabolism by stimulating the activity of several…”