Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers.

By S. Santra, Peng Zhang, Kemin Wang, and Rovelyn Tapec, Wei-Lin Tan. Analytical Chemistry, 2001

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Cancer nanotechnology: opportunities and challenges (2005, methodology): “For instance, fluorophore-laden silica beads have been used for the optical identification of leukaemia cells in blood sample”
Fluorescence Silica Nanoprobe as a Biomarker for Rapid Detection of Plant Pathogens (2009, background): “Recently, Santra et al. (2001) clearly demonstrated that luminophore-doped silica nanoparticles using the water-in-oil (W/O) microemulsion method have many advantages including high fluorescent intensity, photostability, simple operation for leukemia cell identification, and uniform and smooth…”
Luminescent nanomaterials for biological labelling (2005, background): “Problems often encountered with polymer-coated nanobeads include a larger particle size, swelling, particle agglutination, agglomeration and the leaking of fluorophores through tiny surface defects [166].”
In vitro toxicity of silica nanoparticles in human lung cancer cells. (2006, methodology): “…and hypoxanthine levels in rat striatum (Zhang et al., 2004), biomarkers for leukemia cell identification using optical microscopy imaging (Santra et al., 2001), cancer therapy (Hirsch et al., 2003), DNA delivery (Bharali et al., 2005; Gemeinhart et al., 2005), drug delivery (Venkatesan…”