Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation.
By N. H. Uhlenhaut, S. Jakob, Katrin Anlag, T. Eisenberger, R. Sekido, Jana Kress, Anna-Corina Treier, Claudia B. Klugmann, C. Klasen, Nadine I. Holter and 5 more. Cell, 2009
885 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology, Reproductive Medicine
View Paper: https://www.semanticscholar.org/paper/283aeec80d6c817c4e03eabff0d410f4320bc8a6
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
In Molecular Biology
Citations in the corpus
- Conversion of Adult Pancreatic α-cells to β-cells After Extreme β-cell Loss (2010, positive): “These results indicate that: (1) formation of new b-cells from non-b cell origins occurs very rapidly after ablation (about 20% and 90% of them were not labelled 2 weeks and 1 month after DT treatment, respectively), and (2) escaping b-cells probably do not contribute to the expansion of the b-cell ”
- Plasmacytoid Dendritic Cells: Recent Progress and Open Questions (2011, background): “A dramatic example is the conversion of adult ovaries into testes after somatic loss of the ovary-specific transcription factor FoxL2 (61).”
- DMRT1 prevents female reprogramming in the postnatal mammalian testis (2011, methodology): “0 software(30) was used to: (1) log base 2 transform the data; (2) filter the data set for genes that showed at least three observations with abs(val) .”
- Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, neutral): “…of Foxl2 in adult ovarian follicles led to the upregulation of testis-specific genes, resulting in reprogramming of granulosa and theca cells into functional Sertoli-like and Leydig-like cells, respectively, which were capable of expressing normal testosterone levels (Uhlenhaut et al., 2009).”