Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms

By M. Massari, C. Murre. Molecular and Cellular Biology, 2000

1,857 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/279f02e2e821df40bb7dea6f9afc1bd0e2d530e4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Transcriptional regulatory elements in the human genome. (2006, neutral): “TFBS sequence variations may also direct a preference for certain dimerization partners over others (37, 124, 142).”
ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. (2000, background): “Some HLH proteins also bind the related ‘N box’ sequence, CACNAG (Massari and Murre, 2000).”
HES and HERP families: Multiple effectors of the notch signaling pathway (2003, background): “Over 240 HLH proteins have been identified to date in organisms ranging from yeast to human (Massari and Murre, 2000).”
The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription (2005, methodology): “The Eprotein sub-family of bHLH proteins (Tcf3, Tcf4 and Tcf12) has a crucial role in lymphocyte differentiation (Engel and Murre, 2001; Greenbaum and Zhuang, 2002), and its family members also function as heterodimer partners for many of the tissue-restricted bHLH proteins, such as Myod and Neurod ”
Building muscle: molecular regulation of myogenesis. (2012, background): “The basic domain of the MRFs mediates DNA binding, whereas the helix– loop–helix motif is required for heterodimerization with E proteins that mediate the recognition of genomic Eboxes, a motif found in the promoters of many muscle-specific genes (Massari and Murre 2000).”
Transcriptional regulatory networks in cellular responses and tolerance to dehydration and cold stresses. (2006, background): “ICEr1 contains the sequence CACATG, which includes a consensus recognition site for bHLH proteins, CANNTG (73).”
Evolutionary and comparative analysis of MYB and bHLH plant transcription factors. (2011, background): “…nucleotide. bHLH domains with at least five basic amino acids in the basic region and a highly conserved HER motif (His5–Glu9–Arg13), which is found in more than 50% of plant bHLHs, are predicted to bind DNA (Figure 3) (Atchley and Fitch, 1997; Massari and Murre, 2000; Toledo-Ortiz et al., 2003).”
The TT8 Gene Encodes a Basic Helix-Loop-Helix Domain Protein Required for Expression of DFR and BAN Genes in Arabidopsis Siliques (2000, background): “The corresponding protein displays the typical features of a transcription factor with a bHLH signature at its C terminus, a domain found in all animal c-MYC–related proteins (Massari and Murre, 2000).”
HFR1 encodes an atypical bHLH protein that acts in phytochrome A signal transduction (2000, background): “Many animal bHLH proteins act as components of complex regulatory networks that include cross-dimerizing DNA-binding activators and repressors of transcription, as well as HLH inhibitors of bHLH DNA-binding (Littlewood and Evan 1998; Atchley et al. 1999; Massari and Murre 2000).”