DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status
By K. Sinclair, C. Allegrucci, Ravinder Singh, D. Gardner, S. Sebastian, J. Bispham, A. Thurston, J. Huntley, W. Rees, Christopher A. Maloney and 4 more. Proceedings of the National Academy of Sciences of the United States of America, 2007
831 citations recorded by the source corpus.
Subfields: Molecular Biology, Pediatrics, Perinatology and Child Health
View Paper: https://www.semanticscholar.org/paper/2789fd79f2be9c47a4e96f5f16afd4f1ee918ba7
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
Citations in the corpus
- DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. (2009, background): “Our observation that the methylation changes in relation to the prenatal environment may be sex-specific is in agreement with the sex-specific methylation changes found in offspring of sheep that were folate- and vitamin B12-restricted during periconception (29).”
- Influence of Metabolism on Epigenetics and Disease (2013, positive): “Studies in rodents and sheep have confirmed that the availability of nutrients required for one-carbon metabolism (for example, folate, choline, methionine, and betaine, as well as selected B vitamins) at the time of conception and during pregnancy can induce epigenetically driven phenotypes in thei”
- Persistent epigenetic differences associated with prenatal exposure to famine in humans (2008, background): “Animal studies have indicated that certain transient environmental influences can produce persistent changes in epigenetic marks that have life-long phenotypic consequences (3, 4).”