Interactome: gateway into systems biology.

By Michael E. Cusick, Niels Klitgord, Marc Vidal, David E. Hill. Human Molecular Genetics, 2005

427 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2724eb13e88144dc3f2c967a147a9d550b49117b

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Citations in the corpus

Systematic Functional Annotation and Visualization of Biological Networks (2016, background): “While protein-protein interactions are known to be highly nonrandom and to preferentially connect members of the same protein complex and other functionally related proteins (Cusick et al., 2005), a genome-wide map of the network, produced by the spring-embedded layout algorithm, showed no visible t”
Literature-curated protein interaction datasets (2009, background): “(1) Is there any information in the paper that supports the interaction? (2) Has the experiment supporting the interaction been done at low throughput? Since the perception persists that low-throughput experiments have greater reliability21 knowing this is important.”
Inference of direct residue contacts in two-component signaling. (2010, background): “Still, not all protein complexes are as inherently stable as the above-mentioned examples (Cusick et al., 2005).”
Identification of direct residue contacts in protein–protein interaction by message passing (2009, methodology): “[1] is an algorithmically hard task, and can be achieved using a two-step procedure.”
Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks (2010, background): “The complete map of protein interactions that can occur in a living organism is called the interactome [3].”
HINT: High-quality protein interactomes and their applications in understanding human disease (2012, background): “Background Numerous recent efforts in systems biology have tried to characterize the set of all possible pairwise physical interactions or the binary protein “interactome” of an organism [1-3].”
The biological impact of mass-spectrometry-based proteomics (2007, background): “Functional characterization of protein complexes Many proteins function as components of complexes in cells and tissue”
PINA v2.0: mining interactome modules (2011, background): “A common type of analysis focuses on the whole network of protein interactions for a given species (‘interactome’) (1).”
FireDock: a web server for fast interaction refinement in molecular docking (2008, background): “(1) Side-chain optimization: The side-chain flexibility of the receptor and the ligand is modeled by a rotamer library.”