Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions
By N. Hiraoka, K. Onozato, T. Kosuge, S. Hirohashi. Clinical Cancer Research, 2006
810 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/2672ae292e69c4885e3f6808d67190d85f462111
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- C. Sautès-Fridman
- T. Hagemann
- G. Miller
- Franck Pagès
- M. Capasso
- F. Balkwill
- J. Joyce
- Lisa M. Coussens
In Oncology
- C. Sautès-Fridman
- T. Hagemann
- G. Miller
- M. Capasso
- F. Balkwill
- J. Joyce
- Lisa M. Coussens
- A. Mantovani
Citations in the corpus
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Diminished Survival (2014, neutral): “In summary, our study, together with other ongoing efforts to elucidate pancreatic tumor immunity and immunotherapy (Bayne et al., 2012; Clark et al., 2007; Hiraoka et al., 2006; Roberts et al., 2013; Vonderheide et al., 2013), will likely offer insights into potential efficacy of combination therap”
- The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis (2011, methodology): “We designed a broad PubMed and Embase search, using the following terms:”
- Immune infiltration in human tumors: a prognostic factor that should not be ignored (2010, background): “It was confirmed in other solid tumors, such as pancreatic ductal adenocarcinoma (Hiraoka et al., 2006b) and hepatocarcinoma (Fu et al., 2007).”
- The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression (2018, positive): “FOXP3+ Tregs also facilitate tumor immune escape in PDA (22).”
- Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer (2013, methodology): “Immunohistochemistry was performed on the formalin-fixed, paraffin-embedded tissue sections using the avidin–biotin complex method as described previously (Hiraoka et al, 2006).”
- The tumor microenvironment at a glance (2012, background): “High numbers of Tregs in the TME correlate with worse prognosis in many types of cancer (Bates et al., 2006; Curiel et al., 2004; Hiraoka et al., 2006).”