Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells.

By M. Arpinati, C. Green, S. Heimfeld, Jill E. Heuser, C. Anasetti. Blood, 2000

612 citations recorded by the source corpus.

Subfields: Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/2625fb3a8ad9fcb3aa44e73d9097011c476a1711

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In Immunology

1. Yong‐jun Liu
2. G. Trinchieri
3. M. Gilliet
4. M. Colonna
5. A. Krieg
6. A. O’Garra
7. A. Lanzavecchia
8. A. Thomson

Citations in the corpus

• Tolerogenic dendritic cells and the quest for transplant tolerance (2007, background): “Interestingly, G-CSF increases the percentage of pDCs in blood stem-cell products, without altering the number of myeloid DC”
• Dendritic cell lineage, plasticity and cross-regulation (2001, background): “Whereas CD40 ligand (CD40L)-activated myeloid DC1s derived from monocytes produce a large amount of IL-12 and preferentially induce T H 1 development, CD40L-activated lymphoid DC2s derived from plasmacytoid precursors produce lower amounts of IL-12 and preferentially induce T H 2 developmen”
• The Development of Murine Plasmacytoid Dendritic Cell Precursors Is Differentially Regulated by FLT3-ligand and Granulocyte/Macrophage Colony-Stimulating Factor (2002, background): “954 Murine Plasmacytoid DC Development IPCs in the blood of human volunteers (12, 13).”
• Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization (2000, background): “Many PDCs have been observed in human granulocyte colony-stimulating factor (G-CSF)-mobilized stem cells and it was proposed that PDCs suppress graft- versus -host disease (GVHD) in allogeneic transplantation by inducing IL-4– and IL-10–producing T cell”
• Generation of Human CD8 T Regulatory Cells by CD40 Ligand–activated Plasmacytoid Dendritic Cells (2002, result): “This hypothesis is supported by a recent study showing that transplantation of GM-CSF– mobilized blood cells, which contain increased numbers of DC2 precursors, induced less severe GVHD (38).”
• Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells1 (2004, background): “Several clinical studies indicated that PDCs may play an important role in modulating immune responses after HCT to facilitate engraftment and prevent GVHD reactions (64, 65).”
• Plasmacytoid dendritic cells in immunity (2004, background): “Another important cytokine in pDC biology is granulocyte colony-stimulating factor, which promotes pDC mobilization from bone marro”